Methods: The PIVUS cohort study is an observational study of 1016 (509 women and 507 men) randomly chosen individuals aged 70 living in Uppsala, Sweden. Carotid artery ultrasound measurements were performed. IMT and the grey scale median (GSM) value were calculated in the intima-media complex

Uppsala Seniors (PIVUS) cohort (nD1,016). A score of ﬁve previously published single nucleotide polymorphisms (SNPs) from genes involved in homocysteine metabolism were utilized as genetic instrument for homocysteine concentrations.The effect estimate of this genetic score withT2D was determined using results from the DIAbetes Genetics Repli-

METHODS: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort provided plasma samples three times from 2001 to 2014. Individuals maintaining the same zip code throughout the study (n = 399) were divided into a reference (no known PFAS exposure), low, intermediate and high exposure area depending on the proportion of contaminated drinking water received. These findings suggest an activation of vascular adhesion molecules by POPs, and particularly by PCB-126. Citation: Kumar J, Lind PM, Salihovic S, van Bavel B, Ingelsson E, Lind L. 2014. Persistent organic pollutants and inflammatory markers in a cross-sectional study of elderly Swedish people: The PIVUS cohort. These individuals were recruited from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort.

Pivus cohort

PIVUS analyseswerealsoadjustedfor2principalcomponents to adjust for population stratification. We used fixed effects with inverse variance weighting in the meta-analysis of the results for the 2 cohorts. Heterogeneity in … These individuals were recruited from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. We used a total toxic equivalency (TEQ) value that measures toxicological effects with the relative potencies of various POPs. In the PIVUS cohort, GFR was estimated using Gentian reagents (Moss, Norway) according to the formula: estimated GFR = 79.901*cystatin C¯ 1·4389 in PIVUS. Both formulas for the calculation of GFR are closely correlated with plasma iohexol clearance 25 , 26 .

The Results: Concentrations of EVs were higher in the ARISTOTLE patients than in the PIVUS cohort for all the EV groups except EVs from endothelial cells (p . 0.0001). The distributions of the concentrations of the EVs were similar among the control group and the stroke cases for all of the sources of EVs in the ARISTOTLE study.

The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS)study is a population-based longitudinal cohort study, started in 2001, of men and women aged 70.

The ULSAM cohort included only men, whilst the PIVUS cohort had a balanced sex ratio Stroke is the most common clinical manifestation of vascular disease in the brain. We have assembled a cohort study of >200000 stroke patients, registered in Riksstroke (the Swedish Stroke Register) during 2001 through 2009, and a separate cohort study also including TIA-patients for the years 2011 through 2014. in the male samples from the PIVUS cohort.

These individuals were recruited from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. We used a total toxic equivalency (TEQ) value that measures toxicological effects with the relative potencies of various POPs.

Fasting blood samples were taken and anticoagulated with citrate. Plasma was prepared by centrifugation at 2000 ×g for 20 min, then frozen and stored at −70 °C.

Jennifer PIVUS – fractures and body composition. clinical (SMCC), Cohort of Swedish Men. (COSM) and The Prospective Investigation in the Vasculature of Uppsala Seniors (PIVUS). The age range of In a cohort of 42 subjects with different levels of glucose tolerance (normal, Small Vessel Disease on Neuroimaging in a 75-Year-Old Cohort (PIVUS): pivus-studien (Prospective Investigation of Vas- culature in Uppsala Seniors, pivus). Förutom en omfattande mortality in a cohort of.
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2011-09-14 2013-12-01 Of these 26 proteins, five were replicated in the PIVUS cohort in the same multivariable model (in order of significance: T-cell immunoglobulin mucin 1 (TIM-1), placenta growth factor (PlGF), growth/differentiation factor 15 (GDF-15), kallikrein-11 (hK11) and urokinase plasminogen activator surface receptor (U … One SNP, rs2179922 located in intron 4 of ESR1 showed and association signal (p = 0.0056) in the male samples from the PIVUS cohort. Homozygote carriers of the G-allele of the SNP rs2179922 were on average 0.90 cm taller than individuals with the two other genotypes at this SNP in the ULSAM cohort and 2.3 cm taller in the PIVUS cohort. One SNP, rs2179922 located in intron 4 of ESR1 showed and association signal (p = 0.0056) in the male samples from the PIVUS cohort. Homozygote carriers of the G-allele of the SNP rs2179922 were on average 0.90 cm taller than individuals with the two other genotypes at this SNP in the ULSAM cohort and 2.3 cm taller in the PIVUS cohort: the influence of CRP, IL-6, and cystatin C eTable 4. Relationship of serum cathepsin S to cancer mortality in the ULSAM cohort: the influence of CRP, IL-6, and cystatin C eTable 5.

Rambaut, Andrew; Loman, Nick; Pybus, Oliver; Barclay, Wendy; Barrett, Jeff; with SARS-CoV-2 variant of concern 202012/1: matched cohort study” (på ted a prospective, matched cohort study to examine abetes: a cohort study of 33 453 patients från den så kallade PIVUS-stu- dien där ett elderly cohort The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Atherosclerosis. 2007 Feb 27; [Epub ahead of print]. 259.
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PIVUS cohort Dioxin 2017 MTM research group Olle Engkvist Travel Grant References: Salihovic, S., et al., Circulating levels of Persistent Organic Pollutants (POPs) among elderly men and women from Sweden: Results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS). Environment International, 2012. 44: p. 59-67.

Small Vessel Disease on Neuroimaging in a 75-Year-Old Cohort (PIVUS): Comparison With Cognitive and Executive Tests Front Aging Neurosci . 2018 Jul 16;10:217.

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Jun 16, 2020 This prospective cohort study, “Prospective Imaging Study of Ageing: Genes, Brain and Behaviour” (PISA) seeks to characterise the phenotype

Life Science in Sweden by Horn Publishing / Horn Forlag - issuu. PDF) Population-based cardiovascular cohort studies in Uppsala Graden av diversifiering inom platser för varje gen undersöktes med hjälp av trädformen statistik-y (Pybus och Harvey, 2000), beräknad från ultrametriska träd. Small Vessel Disease on Neuroimaging in a 75-Year-Old Cohort (PIVUS): Comparison With Cognitive and Executive Tests Front Aging Neurosci . 2018 Jul 16;10:217.

investigations in PIVUS and ULSAM were performed using stan-dardized methods including measurements of blood pressure, bio-chemistry(lipidsandglucose),anthropometry,electrocardiogramand echocardiography (PIVUS only), as well as a questionnaire regard-ing medical history, smoking habits, and medications (Supplemen-tary material online, Methods).

15 In total, 1016 people (507 women and 499 men) took part in the investigation (participation rate=50.1%). Abbreviations: PIVUS, The Prospective Study of the Vasculature in Uppsala Seniors; POEM, The Prospective investigation of Obesity Energy and Metabolism; SAVa, Study of Atherosclerosis in V¨astmanland; PADVa, Peripheral Arterial Disease in V¨astmanland; BMI, Body Mass Index; COPD, Chronic Obstructive Pulmonary The first population-based cohort study in Uppsala with the aim to study cardiovascular disease was initiated in 1970 (ULSAM). This cohort of 2300 middle-aged men has since then been followed in a longitudinal fashion for almost 50years. This study has been followed by the PIVUS study, investigat-ing 1000 men and women at ages 70, 75, and 80. Persistent Organic Pollutants and Inflammatory Markers in a Cross-Sectional Study of Elderly Swedish People: The PIVUS Cohort.

Recent analyses using two independent cohorts (ULSAM and PIVUS) showed an association between LOY in blood. 31 Jul 2015 Research Design and Methods: Two community-based cohorts of To our knowledge, PIVUS is the largest cohort with repeated sTNFR1 7 Oct 2014 from two large cohorts, the population-based PIVUS cohort (N = 406, Alzheimer disease Neuroimaging Initiative (ADNI) cohort (N = 724).